Glucocorticoids synergize with IL-1 beta to induce TLR2 expression via MAP kinase phosphatase-1-dependent dual inhibition of MAPK JNK and p38 in epithelial cells
Andrew CB Cato
- 生命科学－已发表论文 
Background: Despite the importance of glucocorticoids in suppressing immune and inflammatory responses, their role in enhancing host immune and defense response against invading bacteria is poorly understood. Toll-like receptor 2 (TLR2) has recently gained importance as one of the major host defense receptors. The increased expression of TLR2 in response to bacteria-induced cytokines has been thought to be crucial for the accelerated immune response and resensitization of epithelial cells to invading pathogens.