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dc.contributor.authorBradley, K.zh_CN
dc.contributor.authorScatizzi, J. C.zh_CN
dc.contributor.authorFiore, S.zh_CN
dc.contributor.authorShamiyeh, E.zh_CN
dc.contributor.authorKoch, A. E.zh_CN
dc.contributor.authorFirestein, G. S.zh_CN
dc.contributor.authorGorges, L. L.zh_CN
dc.contributor.authorKuntsman, K.zh_CN
dc.contributor.authorPope, R. M.zh_CN
dc.contributor.authorMoore, T. L.zh_CN
dc.contributor.authorHan, J. H.zh_CN
dc.contributor.authorPerlman, H.zh_CN
dc.contributor.author韩家淮zh_CN
dc.date.accessioned2013-12-12T02:24:38Z
dc.date.available2013-12-12T02:24:38Z
dc.date.issued2004zh_CN
dc.identifier.citationArthritis and Rheumatism,50(1):78-87zh_CN
dc.identifier.issn0004-3591zh_CN
dc.identifier.otherISI:000188085600010zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65723
dc.description.abstractObjective. Rheumatoid arthritis (RA) is characterized by increased synovial lining cellularity, inflammation, and destruction of cartilage and bone. During the pathogenesis of RA, synovial fibroblasts reenter the cell cycle and multiply in number. RA synovial fibroblasts express high levels of the MAP kinase p38, which may contribute to the production of interleukin-6 (IL-6) and matrix metalloproteinases (MMPs). IL-6 and MMP-1 promote inflammation and joint destruction, respectively. Taken together, these findings indicate that in RA the enhanced cell cycle activity and production of IL-6 and MMP-1 may be linked. Therefore, we sought to determine if the tumor suppressor gene product retinoblastoma (Rb), a negative regulator of cell cycle activity, inhibits IL-6, MMP-1, and p38 in RA synovial fibroblasts.zh_CN
dc.language.isoen_USzh_CN
dc.subjectACTIVATED PROTEIN-KINASEzh_CN
dc.subjectCOLLAGEN-INDUCED ARTHRITISzh_CN
dc.subjectTUMOR-NECROSIS-FACTORzh_CN
dc.subjectN-TERMINAL KINASEzh_CN
dc.subjectMATRIX METALLOPROTEINASE-1zh_CN
dc.subjectMULTIPLE-MYELOMAzh_CN
dc.subjectGENE-EXPRESSIONzh_CN
dc.subjectTRANSCRIPTION FACTORSzh_CN
dc.subjectCELL-PROLIFERATIONzh_CN
dc.subjectSOMATIC MUTATIONSzh_CN
dc.titleRetinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblastszh_CN
dc.typeArticlezh_CN


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