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dc.contributor.authorLi, Z. C.zh_CN
dc.contributor.authorChen, L. H.zh_CN
dc.contributor.authorYu, X. J.zh_CN
dc.contributor.authorHu, Y. H.zh_CN
dc.contributor.authorSong, K. K.zh_CN
dc.contributor.authorZhou, X. W.zh_CN
dc.contributor.authorChen, Q. X.zh_CN
dc.contributor.author陈清西zh_CN
dc.date.accessioned2013-12-12T02:24:35Z
dc.date.available2013-12-12T02:24:35Z
dc.date.issued2010-12-08zh_CN
dc.identifier.citationJournal of Agricultural and Food Chemistry, 2010,58(23):12537-12540zh_CN
dc.identifier.issn0021-8561zh_CN
dc.identifier.otherISI:000284672800068zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65674
dc.description.abstract2-Chlorobenzaldehyde thiosemicarbazone (2-Cl-BT) and 4-chlorobenzaldehyde thiosemicarbazone (4-Cl-BT) were synthesized, and their inhibitory kinetics on the activity of mushroom tyrosinase were investigated. Results showed that these compounds exhibited significant inhibitory potency on both monophenolase activity and diphenolase activity of tyrosinase. For the monophenolase activity, both compounds could decrease the steady-state activity of the enzyme sharply, without any influence on the lag period. The IC(50) values of them were estimated to be 15.4 mu M and 6.7 mu M, respectively. For the diphenolase activity, both compounds belonged to reversible inhibitors, but their mechanisms were different: 2-Cl-BT was a noncompetitive type inhibitor, while 4-Cl-BT was a mixed-type inhibitor. Their inhibition constants were determined and compared.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1021/jf1033625zh_CN
dc.subjectANALOGSzh_CN
dc.subjectAGENTSzh_CN
dc.subjectACIDzh_CN
dc.subjectDERIVATIVESzh_CN
dc.subjectOXIDATIONzh_CN
dc.subjectMECHANISMzh_CN
dc.subjectMELANOMAzh_CN
dc.titleInhibition Kinetics of Chlorobenzaldehyde Thiosemicarbazones on Mushroom Tyrosinasezh_CN
dc.typeArticlezh_CN


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