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dc.contributor.authorZhang, Jiliangzh_CN
dc.contributor.authorZuo, Zhenghongzh_CN
dc.contributor.authorXiong, Jianlizh_CN
dc.contributor.authorSun, Pingzh_CN
dc.contributor.authorChen, Yixinzh_CN
dc.contributor.authorWang, Chonggangzh_CN
dc.contributor.author陈奕欣zh_CN
dc.date.accessioned2013-12-12T02:24:31Z
dc.date.available2013-12-12T02:24:31Z
dc.date.issued2013-01zh_CN
dc.identifier.citationChemosphere, 2013,90(3):1294-1299zh_CN
dc.identifier.issn0045-6535zh_CN
dc.identifier.otherWOS:000312978700053zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65600
dc.description.abstractTributyltin (TBT) is a well-studied endocrine disruptor in mollusks and fishes. Recently, TBT is also recognized as a metabolic disruptor. Since abnormal lipids metabolism can induce negative effects on reproduction, the present study was designed to investigate the effects of TBT on ovarian lipid accumulation and testosterone esterification in rockfish (Sebastiscus marmoratus). After exposure for 48d, there was a decrease of neutral lipid droplets in the ooplasm of ovaries. Exposure has also induced lipotoxicity responses in the ovaries, which shown as an increase of interstitial ectopic lipid accumulation and total lipids. The decrease of serum triiodothyronine and thyroxine concentrations might be responsible for the lipotoxicity responses. In addition, the percentage of testosterone in an esterified form was significantly decreased in the ovaries by TBT exposure, which might be a mechanism by which free testosterone levels increased. The accumulation of ectopic lipids and increase of free testosterone levels in the ovaries might impact ovarian functions and oocyte development in fish. These results strongly indicate that TBT exposure can influence reproductive functions of rockfish through lipotoxic mechanism.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.chemosphere.2012.10.078zh_CN
dc.titleTributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratuszh_CN
dc.typeArticlezh_CN


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