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dc.contributor.authorSong, Gangzh_CN
dc.contributor.authorWang, Weiweizh_CN
dc.contributor.authorHu, Tianhuizh_CN
dc.contributor.author胡天惠zh_CN
dc.date.accessioned2013-12-12T02:24:21Z
dc.date.available2013-12-12T02:24:21Z
dc.date.issued2011-09zh_CN
dc.identifier.citationMedical Hypotheses, 2011,77(5):850-852zh_CN
dc.identifier.issn0306-9877zh_CN
dc.identifier.otherWOS:000296684500033zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65442
dc.descriptionNational Natural Science Foundation of China [31071187]; Xiamen municipal science and technology innovation fund [3502Z20114018]; Fundamental Research Funds for the Central Universities [2010121102]zh_CN
dc.description.abstractOver the past decade, the BH3-only BID likes p53, has emerged as a central player in linking death signals through surface death receptors to the core apoptotic mitochondrial pathway and life signals through cell cycle arrest. Recent studies indicate that pro-apoptotic activation of BID may be negatively regulated by its phosphorylation in response to DNA damage. BID itself plays a role in cell cycle checkpoint response, in DNA repair, or in integrating apoptosis and the DNA damage response, which indicate BID is a nuclear-cytoplasmic protein. However, BID does not have any obvious nuclear localization signals (NLS), and only carries nuclear export signals (NES). Mutating BID NES does not affect the nuclear exit of BID, suggesting that BID NES does not seem to function as a NES. Therefore, BID is transported into the nucleus and its export is probably mediated by other NES-carrying proteins. As a well-characterized transcription factor, p53 carries typical NLS and NES. Bid is transcriptionally regulated by p53, and both can be exported from nucleus to the mitochondria in response to DNA damage. Moreover, p53 can, through the interaction with BID in the mitochondria to induce apoptosis. Given the above background, we hypothesize that p53 facilitates BID nuclear export to induce apoptosis in response to irreparable DNA damage. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.mehy.2011.07.052zh_CN
dc.subjectHEPATOCELLULAR-CARCINOMAzh_CN
dc.subjectCELL-PROLIFERATIONzh_CN
dc.subjectDEATHzh_CN
dc.subjectINHIBITIONzh_CN
dc.subjectACTIVATIONzh_CN
dc.subjectSURVIVALzh_CN
dc.titlep53 Facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage responsezh_CN
dc.typeArticlezh_CN


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