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dc.contributor.authorDu, X. P.zh_CN
dc.contributor.authorLu, C. H.zh_CN
dc.contributor.authorLi, Y. Y.zh_CN
dc.contributor.authorZheng, Z. G.zh_CN
dc.contributor.authorSu, W. J.zh_CN
dc.contributor.authorShen, Y. M.zh_CN
dc.contributor.author沈月毛zh_CN
dc.date.accessioned2013-12-12T02:24:15Z
dc.date.available2013-12-12T02:24:15Z
dc.date.issued2008-04zh_CN
dc.identifier.citationJournal of Antibiotics, 2008,61(4):250-253zh_CN
dc.identifier.issn0021-8820zh_CN
dc.identifier.otherISI:000255923700008zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65347
dc.description.abstractTwo new 10-membered macrolides, named Phomolides A (1) and B (2), and one new derivative of benzofuran (3) were isolated from the culture of Phomopsis sp. hzla01-1, and their structures were elucidated based on spectroscopic analyses, particularly 2D NMR experiments. Compounds 1, 2 and 3 showed significant antimicrobial activities against Escherichia coli CMCC44103, Candida alhicans AS2.538, Saccharomyces cerevisiae ATCC9763 with MICs 5 similar to 10 mu g/ml. The most significant, compound 3 showed strong activity against Bacillus subtilis CMCC63501 with the MIC value 1.25 mu g/ml. None of the three compounds showed significant cytotoxicity against the HeLa cell line at 10 mu g/ml.zh_CN
dc.language.isoen_USzh_CN
dc.subjectMARINE-DERIVED FUNGUSzh_CN
dc.subjectRED ALGA POLYSIPHONIAzh_CN
dc.subjectCHOLESTEROL-BIOSYNTHESISzh_CN
dc.subjectSECONDARY METABOLITESzh_CN
dc.subjectPENICILLIUMzh_CN
dc.subjectDECARESTRICTINESzh_CN
dc.subjectINHIBITORSzh_CN
dc.subjectFAMILYzh_CN
dc.titleThree new antimicrobial metabolites of Phomopsis spzh_CN
dc.typeArticlezh_CN


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