Macrolides of the bafilomycin family produced by Streptomyces sp CS
Li, J. A.
Lu, C. H.
Shen, Y. M.
- 生命科学－已发表论文 
Five new 16-membered macrolides (1-5), belonging to the bafilomycin subfamily, were isolated from the fermentation broth of Streptomyces sp CS, a commensal microbe of Maytenus hookeri Their structures including relative configurations were elucidated based on NMR data and analysis of single crystal X-ray diffraction data The cytotoxicities of compounds 1-5 on the MDA-MB 435 cell line were analyzed by the MTT method and the IC(50) values were found to be 4 2, 4 5, 5 5, 3 8 and 11 4 mu M, respectively The Journal of Antibiotics (2010) 63, 595-599, doi 10 1038/ja 2010 95, published online 8 September 2010