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dc.contributor.authorLiang, X. H.zh_CN
dc.contributor.authorZhao, Z. A.zh_CN
dc.contributor.authorDeng, W. B.zh_CN
dc.contributor.authorTian, Z.zh_CN
dc.contributor.authorLei, W.zh_CN
dc.contributor.authorXu, X.zh_CN
dc.contributor.authorZhang, X. H.zh_CN
dc.contributor.authorSu, R. W.zh_CN
dc.contributor.authorYang, Z. M.zh_CN
dc.contributor.author杨增明zh_CN
dc.date.accessioned2013-12-12T02:24:08Z
dc.date.available2013-12-12T02:24:08Z
dc.date.issued2010-10zh_CN
dc.identifier.citationEndocrinology, 2010,151(10):5007-5016zh_CN
dc.identifier.issn0013-7227zh_CN
dc.identifier.otherISI:000282005700041zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65211
dc.descriptionNational Basic Research Program of China [2006CB504005, 2006CB944006]; Chinese National Natural Science Foundation [30770244, 30930013]zh_CN
dc.description.abstractEmbryo implantation is an intricate interaction between receptive uterus and active blastocyst. The mechanism underlying embryo implantation is still unknown. Although histamine and putrescine are important for embryo implantation and decidualization, excess amount of histamine and putrescine is harmful. Amiloride binding protein 1 (Abp1) is a membrane-associated amine oxidase and mainly metabolizes histamine and putrescine. In this study, we first showed that Abp1 is strongly expressed in the decidua on d 5-8 of pregnancy. Abp1 expression is not detected during pseudopregnancy and under delayed implantation but is detected after estrogen activation. Because Abp1 is mainly localized in the decidua and also strongly expressed during in vitro decidualization, Abp1 might play a role during mouse decidualization. The regulation of estrogen on Abp1 is mediated by transcription factor CCAAT/enhancer-binding protein-beta. Abp1 expression is also regulated by cAMP, bone morphogenetic protein 2, and ERK1/2. Abp1 may be essential for mouse embryo implantation and decidualization. (Endocrinology 151: 5007-5016, 2010)zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1210/en.2010-0170zh_CN
dc.subjectDIAMINE OXIDASEzh_CN
dc.subjectNEUROENDOCRINE CANCERSzh_CN
dc.subjectUTERINE ENDOMETRIUMzh_CN
dc.subjectSPERMINE TOXICITYzh_CN
dc.subjectGENE-EXPRESSIONzh_CN
dc.subjectRAT UTERUSzh_CN
dc.subjectHISTAMINEzh_CN
dc.subjectCELLSzh_CN
dc.subjectDIFFERENTIATIONzh_CN
dc.subjectPREGNANCYzh_CN
dc.titleEstrogen Regulates Amiloride-Binding Protein 1 through CCAAT/Enhancer-Binding Protein-beta in Mouse Uterus during Embryo Implantation and Decidualizationzh_CN
dc.typeArticlezh_CN


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