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dc.contributor.authorRen, Jinweizh_CN
dc.contributor.authorLiu, Dongzh_CN
dc.contributor.authorTian, Lizh_CN
dc.contributor.authorWei, Yangyezh_CN
dc.contributor.authorProksch, Peterzh_CN
dc.contributor.authorZeng, Jinzhangzh_CN
dc.contributor.authorLin, Wenhanzh_CN
dc.contributor.author曾锦章zh_CN
dc.date.accessioned2013-12-12T02:24:04Z
dc.date.available2013-12-12T02:24:04Z
dc.date.issued2013-01-01zh_CN
dc.identifier.citationBioorganic & Medicinal Chemistry Letters, 2013,23(1):301-304zh_CN
dc.identifier.issn0960-894Xzh_CN
dc.identifier.otherWOS:000312267700055zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65142
dc.description.abstractFive new phenoxazine-based alkaloids venezuelines A-E (1-5) and two new aminophenols venezuelines F-G (6-7), as well as three known analogues exfoliazone, chandrananimycin D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis. The cytotoxic activity of these compounds against a panel of tumor cell lines were tested, while the regulation of gene target Nur77 of 2 and exfoliazone (8) were evaluated. (c) 2012 Elsevier Ltd. All rights reserved.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.bmcl.2012.10.096zh_CN
dc.subjectStreptomyces venezuelaezh_CN
dc.subjectPhenoxazine-based alkaloidszh_CN
dc.subjectVenezuelineszh_CN
dc.subjectStructural elucidationzh_CN
dc.subjectCytotoxic activityzh_CN
dc.subjectNur77 expressionzh_CN
dc.titleVenezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77zh_CN
dc.typeArticlezh_CN


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