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dc.contributor.authorZhang, Shujunzh_CN
dc.contributor.authorWang, Jingjingzh_CN
dc.contributor.authorYuan, Quanzh_CN
dc.contributor.authorGe, Shengxiangzh_CN
dc.contributor.authorZhang, Junzh_CN
dc.contributor.authorXia, Ningshaozh_CN
dc.contributor.authorTian, Deyingzh_CN
dc.contributor.author张军zh_CN
dc.date.accessioned2013-12-12T02:24:02Z
dc.date.available2013-12-12T02:24:02Z
dc.date.issued2011-04-01zh_CN
dc.identifier.citationVirology Journal, 2011,8zh_CN
dc.identifier.issn1743-422Xzh_CN
dc.identifier.otherWOS:000289888000001zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/65112
dc.description.abstractBackground: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. Results: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. Conclusions: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1186/1743-422X-8-152zh_CN
dc.subjectE VIRUS-INFECTIONzh_CN
dc.subjectWILD BOARzh_CN
dc.subjectSEROPREVALENCEzh_CN
dc.subjectLIVERzh_CN
dc.subjectHEVzh_CN
dc.subjectPOPULATIONzh_CN
dc.subjectCIRRHOSISzh_CN
dc.subjectEPIDEMICzh_CN
dc.subjectOUTBREAKzh_CN
dc.subjectWATERzh_CN
dc.titleClinical characteristics and risk factors of sporadic Hepatitis E in central Chinazh_CN
dc.typeArticlezh_CN


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