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dc.contributor.authorDong Yan ( Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, and The Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)zh_CN
dc.contributor.authorYihui Wu ( Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, and The Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)zh_CN
dc.contributor.authorYing Feng ( Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, and The Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)zh_CN
dc.contributor.authorSheng-Cai Lin
dc.contributor.authorXinhua Lin ( Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, and The Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA)
dc.date.accessioned2011-04-26T08:17:06Z
dc.date.available2011-04-26T08:17:06Z
dc.date.issued2009zh_CN
dc.identifier.citationDEVELOPMENTAL CELL,2009(17)期: 4: 470-481zh_CN
dc.identifier.issn1534-5807zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/6325
dc.description.abstractDally-like (Dlp) is a glypican-type heparan sulfate proteoglycan (HSPG), containing a protein core and attached glycosaminoglycan (GAG) chains. In Drosophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg signaling. Here, we show that Dlp core protein has similar biphasic activity as wild-type Dlp. Dlp core protein can interact with Wg; the GAG chains enhance this interaction. Importantly, we find that Dlp exhibits a biphasic response, regardless of whether its glycosylphosphatidylinositol linkage to the membrane can be cleaved. Rather, the transition from signaling activator to repressor is determined by the relative expression levels of Dlp and the Wg receptor, Frizzled (Fz) 2. Based on these data, we propose that the principal function of Dlp is to retain Wg on the cell surface. As such, it can either compete with the receptor or provide ligands to the receptor, depending on the ratios of Wg, Fz2, and Dlp.zh_CN
dc.description.sponsorshipNational Institutes of Health American Cancer Society March of Dimes American Heart Associationzh_CN
dc.language.isoenzh_CN
dc.publisherCELL PRESSzh_CN
dc.subjectHEPARAN-SULFATE PROTEOGLYCANSzh_CN
dc.subjectLONG-RANGE ACTIONzh_CN
dc.subjectDALLY-LIKEzh_CN
dc.subjectDROSOPHILAzh_CN
dc.subjectHEDGEHOGzh_CN
dc.subjectGRADIENTzh_CN
dc.subjectPATHWAYzh_CN
dc.subjectEXPRESSIONzh_CN
dc.subjectTRANSDUCTIONzh_CN
dc.subjectTRAFFICKINGzh_CN
dc.subject林圣彩zh_CN
dc.titleThe Core Protein of Glypican Daily-Like Determines Its Biphasic Activity in Wingless Morphogen Signalingzh_CN
dc.typeArticlezh_CN


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