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dc.contributor.authorThiel, Austin T.zh_CN
dc.contributor.authorBlessington, Peterzh_CN
dc.contributor.authorZou, Taozh_CN
dc.contributor.authorFeather, Daniellezh_CN
dc.contributor.authorWu, Xinjiangzh_CN
dc.contributor.authorYan, Jizhouzh_CN
dc.contributor.authorZhang, Huizh_CN
dc.contributor.authorLiu, Zuguozh_CN
dc.contributor.authorErnst, Patriciazh_CN
dc.contributor.authorKoretzky, Gary A.zh_CN
dc.contributor.authorHua, Xianxinzh_CN
dc.contributor.author章慧zh_CN
dc.date.accessioned2013-12-12T02:13:29Z
dc.date.available2013-12-12T02:13:29Z
dc.date.issued2010-02-17zh_CN
dc.identifier.citationCancer Cell, 2010,17(2):148-159zh_CN
dc.identifier.issn1535-6108zh_CN
dc.identifier.otherISI:000274766800007zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/63118
dc.descriptionNational Institutes of Health [R01 CA113962]; Leukemia and Lymphoma Society; T32 training [CA09140]zh_CN
dc.description.abstractOncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MILL fusion proteins (MLL-FPs). Here, we show that menin recruits both wild-type MLL and oncogenic MLL-AF9 fusion protein to the loci of HOX genes to activate their transcription. Wild-type MLL not only catalyzes histone methylation at key target genes but also controls distinct MLL-AF9-induced histone methylation. Notably, the wild-type MY allele is required for MLL-AF9-induced leukemogenesis and maintenance of MLL-AF9-transformed cells. These findings suggest an essential cooperation between an oncogene and its wild-type counterpart in MLL-AF9-induced leukemogenesis.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1016/j.ccr.2009.12.034zh_CN
dc.subjectPARTIAL TANDEM DUPLICATIONzh_CN
dc.subjectMIXED-LINEAGE LEUKEMIAzh_CN
dc.subjectTUMOR-SUPPRESSOR MENINzh_CN
dc.subjectACUTE MYELOID-LEUKEMIAzh_CN
dc.subjectHISTONE METHYLTRANSFERASEzh_CN
dc.subjectTRANSCRIPTIONAL ELONGATIONzh_CN
dc.subjectH3K79 METHYLATIONzh_CN
dc.subjectGENE-EXPRESSIONzh_CN
dc.subjectPHD FINGERzh_CN
dc.subjectSTEM-CELLSzh_CN
dc.titleMLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allelezh_CN
dc.typeArticlezh_CN


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