PH-DEPENDENT HYDROLYSIS AND DRUG-RELEASE OF CHITOSAN/POLYETHER INTERPENETRATING POLYMER NETWORK HYDROGEL
- 材料学院－已发表论文 
This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37-degrees-C due to the cleavage of imine bonds within the network. At pH greater-than-or-equal-to 7, there is no hydrolysis. The pH-dependent release of cimetidine from the gel was also investigated.