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dc.contributor.authorSun, Ya-Nanzh_CN
dc.contributor.authorWang, Cai-Dingzh_CN
dc.contributor.authorZhang, Xiu-Mingzh_CN
dc.contributor.authorRen, Leizh_CN
dc.contributor.authorTian, Xin-Huazh_CN
dc.contributor.author任磊zh_CN
dc.date.accessioned2013-12-12T02:02:57Z
dc.date.available2013-12-12T02:02:57Z
dc.date.issued2011-02zh_CN
dc.identifier.citationJournal of Nanoscience and Nanotechnology, 2011,11(2):1210-1216zh_CN
dc.identifier.issn1533-4880zh_CN
dc.identifier.otherWOS:000287167900043zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/58985
dc.descriptionNational Natural Science Foundation of China [30970733]; National Basic Research Program of China (973 Program) [2007CB935603, 2010CB732402]; Fujian Province Universityzh_CN
dc.description.abstractThe toxicity and biodistribution in vivo of various morphologies of Au nanoparticles (AuNPs) were studied by using KM mice. The quantitative analysis of Au in each tissue of mice was done by using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sphere-shaped AuNPs displayed the best biocompatibility, compared with rod- and cube-shaped of AuNPs, and rod-shaped AuNPs was more toxic than cube-shaped AuNPs. In vivo biodistribution study revealed all AuNPs were preferentially accumulated in organ of liver and spleen. The findings from this study thus revealed that the toxicity and biodistribution in vivo of AuNPs are shape dependent.zh_CN
dc.language.isoen_USzh_CN
dc.source.urihttp://dx.doi.org/10.1166/jnn.2011.3094zh_CN
dc.subjectACUTE TOXICITYzh_CN
dc.subjectPARTICLE-SIZEzh_CN
dc.subjectCYTOTOXICITYzh_CN
dc.subjectNANORODSzh_CN
dc.subjectDELIVERYzh_CN
dc.subjectTHERAPYzh_CN
dc.subjectPROBESzh_CN
dc.titleShape Dependence of Gold Nanoparticles on In Vivo Acute Toxicological Effects and Biodistributionzh_CN
dc.typeArticlezh_CN


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