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dc.contributor.author程红芬zh_CN
dc.contributor.author张勇zh_CN
dc.contributor.author宋洁琼zh_CN
dc.contributor.author王增巧zh_CN
dc.contributor.authorCHENG Hong-fenzh_CN
dc.contributor.authorZHANG Yongzh_CN
dc.contributor.authorSONG Jie-qiongzh_CN
dc.contributor.authorWANG Zeng-qiaozh_CN
dc.date.accessioned2013-11-18T07:47:17Z
dc.date.available2013-11-18T07:47:17Z
dc.date.issued2011-02-28zh_CN
dc.identifier.citation电化学,2011,17(01):80-83.zh_CN
dc.identifier.issn1006-3471zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/58393
dc.description.abstract应用线性扫描技术研究盐酸表阿霉素的电化学行为.结果表明,在pH 6.80的Tris-HCl缓冲溶液中,盐酸表阿霉素有一较灵敏的还原峰,Epc=-0.34 V(vs.SCE).加入牛血清白蛋白(BSA)后,盐酸表阿霉素的还原峰电流明显下降.据此,建立了BSA的电化学测定法.在最佳实验条件下,1.0×10-9~1.0×10-6 mol.L-1范围内,BSA浓度与盐酸表阿霉素的峰电流下降值△ip呈线性关系(R=0.9973),BSA检出限达8.05×10-10 mol.L-1.盐酸表阿霉素与BSA的结合比为1,结合常数β为3.04×106 L.mol-1.zh_CN
dc.description.abstractThe linear sweep technique was used to study the electrochemical behavior of epirubicin hydrochloride.The results showed that there was a sensitive reduction peak at-0.34 V(vs.SCE) in pH 6.80 Tris-HCl buffer.When the BSA was added,the value of the reduction peak was reduced deeply.Accordingly,a new electrchemical determintation method of BSA was established.Under the optimum conditions,the decrease of the reduction peak currents of epirubicin hydrochloride were proportional to the concentrations of BSA in the range of 1.0×10-9~1.0×10-6 mol·L-1(R=0.9973).The detection limit of the BSA was 8.05×10-10 mol·L-1.And the binding constant β of the epirubicin hydrochloride and BSA was 3.04×106 L·mol-1 with the ratio of 1.zh_CN
dc.language.isozhzh_CN
dc.publisher厦门大学《电化学》编辑部zh_CN
dc.relation.ispartofseries研究论文zh_CN
dc.relation.ispartofseriesArticleszh_CN
dc.source.urihttp://electrochem.xmu.edu.cn/CN/abstract/abstract8367.shtmlzh_CN
dc.subject盐酸表阿霉素zh_CN
dc.subject牛血清白蛋白(BSA)zh_CN
dc.subject玻碳电极zh_CN
dc.subjectepirubicin hydrochloridezh_CN
dc.subjectbovine serum albumin(BSA)zh_CN
dc.subjectglassy carbon electrodezh_CN
dc.title盐酸表阿霉素与牛血清白蛋白的相互作用和伏安分析zh_CN
dc.title.alternativeInteraction of the Epirubicin Hydrochloride with Bovine Serum Albumin and Its Applicationzh_CN
dc.typeArticlezh_CN
dc.description.note作者联系地址:山西大学化学化工学院;zh_CN
dc.description.noteAuthor's Address: School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,Chinazh_CN


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