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dc.contributor.author陆宝仪zh_CN
dc.contributor.author郑有志zh_CN
dc.contributor.author李红zh_CN
dc.contributor.authorLU Bao-yizh_CN
dc.contributor.authorZHENG You-zhizh_CN
dc.contributor.authorLI Hongzh_CN
dc.date.accessioned2013-11-18T07:46:38Z
dc.date.available2013-11-18T07:46:38Z
dc.date.issued2008-02-28zh_CN
dc.identifier.citation电化学,2008,14(01):34-39.zh_CN
dc.identifier.issn1006-3471zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/58198
dc.description.abstract应用循环伏安法和微分脉冲伏安法研究了6-糠氨基嘌呤(6-KT)和6-巯基嘌呤(6-MP)在汞电极上的电化学行为及与小牛胸腺DNA的相互作用.结果发现,6-KT和6-MP的循环伏安曲线均显示两对分别表征为扩散控制和吸附控制的氧化还原波.扩散控制波的氧化峰电流随6-取代嘌呤浓度在0.1~50.0μmol.L-1范围内呈现良好的线性关系.依据预吸附时间和溶液pH值对吸附控制波的还原峰电位和峰电流的影响,讨论了6-KT和6-MP在汞电极上的吸附机理.作者认为,6-KT乃通过部分插入作用与DNA结合,而6-MP与DNA间的相互作用为静电模式.zh_CN
dc.description.abstractThe electrochemical behavior of 6-furfurylaminopurine(6-KT) and 6-mercaptopurine(6-MP) on a mercury electrode has been investigated using cyclic voltammetry and differential pulse voltammetry.It is found that there are two pairs of redox waves for 6-KT and 6-MP on the mercury electrode controlled by diffusion and adsorption,respectively.The anodic peak currents of the diffusion-controlled wave increase with the adding concentration of 6-substituted purines.A good linear relationship for 6-KT and 6-MP is revealed in the concentration range from 0.1 to 50.0 μmol·L-1.Based on the effects of accumulating time and pH values on the cathodic peak potentials and currents of adsorption-controlled waves,their adsorption mechanism is discussed.The experimental results show that there are interactions of 6-KT and 6-MP with DNA via the intercalative mode partly and electrostatic action,respectively.zh_CN
dc.language.isozhzh_CN
dc.publisher厦门大学《电化学》编辑部zh_CN
dc.relation.ispartofseries研究论文zh_CN
dc.relation.ispartofseriesArticleszh_CN
dc.source.urihttp://electrochem.xmu.edu.cn/CN/abstract/abstract8656.shtmlzh_CN
dc.subject6-糠氨基嘌呤zh_CN
dc.subject6-巯基嘌呤zh_CN
dc.subjectDNAzh_CN
dc.subject电化学行为zh_CN
dc.subject6-furfurylaminopurinezh_CN
dc.subject6-mercaptopurinezh_CN
dc.subjectDNAzh_CN
dc.subjectelectrochemical behaviorzh_CN
dc.title6-取代嘌呤的电化学行为及与DNA的相互作用zh_CN
dc.title.alternativeElectrochemical Behavior of 6-substituted Purines and its Interaction with DNAzh_CN
dc.typeArticlezh_CN
dc.description.note作者联系地址:华南师范大学化学与环境学院,华南师范大学化学与环境学院,华南师范大学化学与环境学院 广东广州510006,广东广州510006,广东广州510006zh_CN
dc.description.noteAuthor's Address: School of Chemistry and Environment,South China Normal University,Guangzhou 510006,Chinazh_CN


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