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dc.contributor.author孙如zh_CN
dc.contributor.author葛健锋zh_CN
dc.contributor.author王梅zh_CN
dc.contributor.author顾仁敖zh_CN
dc.contributor.authorSUN Ruzh_CN
dc.date.accessioned2013-11-18T07:45:33Z
dc.date.available2013-11-18T07:45:33Z
dc.date.issued2004-08-28zh_CN
dc.identifier.citation电化学,2004,10(03):307-313.zh_CN
dc.identifier.issn1006-3471zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/57814
dc.description.abstract 以L 苯丙氨酸为原料经还原反应得到氨基醇,再用Boc基团对中间体进行氨基保护得到(S) 3 苯基 2 叔丁氧羰基氨基 1 丙醇,甲磺酰化后与硫代乙酸钾在DMF中反应得到(S) 3 苯基 2 叔丁氧羰基氨基 1 丙硫醇乙酸酯,再脱除乙酰基后得到目标产物(S) 3 苯基 2 叔丁氧羰基氨基 1 丙硫醇(N Boc APT).分别应用红外光谱、核磁共振对中间体和目标化合物进行表征.同时,利用自组装技术将N Boc APT修饰于金电极表面,并测定其相关的电化学性能;此外,还将金纳米粒子组装在上述修饰电极上,并研究亚甲基蓝于该修饰电极的电化学行为.结果表明,金纳米粒子对该电极过程具有促进作用.zh_CN
dc.description.abstractThe synthesis of (S)-3-Phenylpropane-2-tert-butoxycarbonylamino- 1-thiol(N-Boc-APT) from L-phenylalanine was reported. L-Phenylalanine was reduced to the corresponding amino alcohol, protection of the amino group using tert-butyl pyrocarbonate gave (S)-2-tert-butoxycarbonylamino-3-phenylpropane-1-ol, which was then O-mesylated and treated with potassium thioacetate in DMF to give 3-phenylpropane-2-tert- butoxycarbonylamino-1-etylmercapto. After the acetyl group was removed with ammonia in alcohol, the desired target molecular was obtained. The structure of intermediate and target molecular was conformed by IR and ~(1)HNMR. We made N-Boc-APT self-assemble-modificated gold electrode and investigated its electrochemical behavior. The CV results of methylene blue on nano-Au/N-Boc-APT SAM/Au electrode showed that nano-Au could speed this electron transfer process.zh_CN
dc.language.isozhzh_CN
dc.publisher厦门大学《电化学》编辑部zh_CN
dc.relation.ispartofseries研究论文zh_CN
dc.relation.ispartofseriesArticleszh_CN
dc.source.urihttp://electrochem.xmu.edu.cn/CN/abstract/abstract8999.shtmlzh_CN
dc.subjectN-Boc-APTzh_CN
dc.subject不对称合成zh_CN
dc.subject自组装zh_CN
dc.subject电化学zh_CN
dc.subject金纳米粒子zh_CN
dc.subject亚甲基蓝zh_CN
dc.subject(S)-3-Phenylpropane-2-tert-butoxycarbonylamino-1-thiolzh_CN
dc.subjectAsymmetric synthesiszh_CN
dc.subjectSelf-assembledzh_CN
dc.subjectElectrochemistryzh_CN
dc.subjectGold nanoparticalszh_CN
dc.subjectMethylene bluezh_CN
dc.titleN-Boc-APT合成及其自组装修饰金电极电化学行为zh_CN
dc.title.alternativeSynthesis of (S)-3-Phenylpropane-2-tert-butoxycarbonylamino- 1-thiol and its Electrochemical Behavior Self-assembled on Goldzh_CN
dc.typeArticlezh_CN
dc.description.note作者联系地址:苏州大学化学化工学院,苏州大学材料工程学院,苏州大学化学化工学院,苏州大学化学化工学院 江苏苏州215006 ,江苏苏州215006 ,江苏苏州215006 ,江苏苏州215006zh_CN
dc.description.noteAuthor's Address: 1, GE Jian-feng~2, WANG Mei~1,GU Ren-ao~*1 1. Department of Chemistry and Chemical Engineering, Suzhou University,Jiangsu 215006, China 2.~ Department of Material and Engineering,Suzhou University, Jiangsu 215006,Chinazh_CN


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