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dc.contributor.authorXiaolan Chen
dc.contributor.author陈小兰
dc.contributor.authorZengxia Zhao
dc.contributor.author赵增侠
dc.contributor.authorMengying Jiang
dc.contributor.authorDaiping Que
dc.contributor.authorSaige Shi
dc.contributor.author师赛鸽
dc.contributor.authorNanfeng Zheng
dc.contributor.author郑南峰
dc.date.accessioned2013-07-19T08:12:02Z
dc.date.available2013-07-19T08:12:02Z
dc.date.issued2013-04
dc.identifier.citationNEW JOURNAL OF CHEMISTRY,2013,37(6):1782-1788zh_CN
dc.identifier.issn1144-0546
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/55410
dc.descriptionE-mail Addresses: chenxl@xmu.edu.cn; nfzheng@xmu.edu.cnzh_CN
dc.description.abstractThe preparation, characterization and application of NaYF4:Yb3+, Tm3+-NaYF4:Yb3+, Er3+ core-shell upconversion nanocrystals (UCNPs) with multiple emission peaks (e.g. 539, 654 and 802 nm) have been demonstrated in this work. The monodisperse nanocrystals were prepared via a modified thermal decomposition synthesis. The resulting UCNPs were similar to 31 nm in diameter with the lanthanide ions Tm3+ and Er3+ doped in the core and the shell, respectively. Under the laser diode excitation at 980 nm, these core-shell nanocrystals give strong upconversion emissions from the visible to near-infrared (NIR) region. By coating a PEG-phospholipid (PP) layer on the surface of the nanocrystals, the as-prepared UCNPs were favorably endowed with good water solubility for the potential biological applications. Here, a photosensitizer drug of Chlorin e6 (Ce6), which has maximum absorption that overlaps with the red emission of UCNPs, was loaded on these PP-coated UCNPs (UCNP@PP) by physical adsorption. The activity of the Ce6-loaded UCNP@PP (UCNP@PP-Ce6) in photodynamic therapy of cancer cells in vitro has been fully investigated in this work. Our results indicated that these multifunctional UCNP@PP-Ce6 nanoparticles have efficient NIR-to-NIR upconversion luminescence and photodynamic therapy capabilities, which could be potentially employed as a theranostic platform for cancer treatment.zh_CN
dc.description.sponsorshipNational Natural Science Foundation of China 21101131 21021061 20925103 Natural Science Foundation of Fujian Province 2012J01056 Fundamental Research Funds for the Central Universities 2010121015 Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry NFFTBS J1210014zh_CN
dc.language.isoenzh_CN
dc.publisherROYAL SOC CHEMISTRYzh_CN
dc.subjectUP-CONVERSION FLUORESCENCEzh_CN
dc.subjectRARE-EARTH NANOCRYSTALSzh_CN
dc.subjectDRUG-DELIVERYzh_CN
dc.subjectCANCER-CELLSzh_CN
dc.subjectMONODISPERSE NANOCRYSTALSzh_CN
dc.subjectMAGNETIC-RESONANCEzh_CN
dc.subjectOPTICAL-PROPERTIESzh_CN
dc.subjectSINGLET OXYGENzh_CN
dc.subjectSHELLzh_CN
dc.subjectCOREzh_CN
dc.titlePreparation and photodynamic therapy application of NaYF4:Yb, Tm-NaYF4:Yb, Er multifunctional upconverting nanoparticleszh_CN
dc.typeArticlezh_CN


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