| dc.contributor.advisor | 曾锦章 | |
| dc.contributor.author | 何加友 | |
| dc.date.accessioned | 2016-02-14T07:40:10Z | |
| dc.date.available | 2016-02-14T07:40:10Z | |
| dc.date.issued | 2011-02-25 09:26:45.0 | |
| dc.identifier.uri | https://dspace.xmu.edu.cn/handle/2288/47385 | |
| dc.description.abstract | 核受体是位于细胞内的一类重要的调控蛋白，目前已是药物开发的第二大靶点，迄今开发的药物中有大约13%的药物通过核受体靶点起作用。TR3是核受体家族的重要成员，在细胞分化，细胞增殖，细胞凋亡过程中发挥着关键的调控作用。在某些诱导剂的作用下，TR3可以快速地从细胞核转运到细胞质并且和Bcl-2相互作用，使Bcl-2从一个抑制凋亡的分子转变成促进细胞凋亡的杀手。由于许多治疗药物可通过调控细胞凋亡起作用，该发现提示，TR3调控的凋亡通路是开发抗肿瘤药物的新靶点。 本研究的目的就是建立一个以TR3为靶点的抗肿瘤药物筛选系统，该系统包括了药物对于TR3的表达调控，对于TR3在细胞内分区情况的影响，以及通过... | |
| dc.description.abstract | Nuclear receptors (NRs), a class of proteins found within cells, represent the second most common drug target with about 13% of existing drugs acting on nuclear receptors. The orphan nuclear receptor TR3 (also known as NGFIB and Nur77) is an important member of the nuclear receptor superfamily which plays a key role in the regulation of differentiation, proliferation, apoptosis, and survival of ma... | |
| dc.language.iso | zh_CN | |
| dc.relation.uri | https://catalog.xmu.edu.cn/opac/openlink.php?strText=26877&doctype=ALL&strSearchType=callno | |
| dc.source.uri | https://etd.xmu.edu.cn/detail.asp?serial=26906 | |
| dc.subject | 核受体 | |
| dc.subject | TR3 | |
| dc.subject | 药物筛选 | |
| dc.subject | 细胞凋亡 | |
| dc.subject | nuclear receptors | |
| dc.subject | TR3 | |
| dc.subject | drug screening | |
| dc.subject | apoptosis | |
| dc.title | 以孤儿受体TR3为分子靶点的抗肿瘤药物筛选 | |
| dc.title.alternative | Screening for Anti-cancer Drugs Targeting Orphan Nuclear Receptor TR3 | |
| dc.type | thesis | |
| dc.date.replied | 2010-05-29 | |
| dc.description.note | 学位：理学硕士 | |
| dc.description.note | 院系专业：生物医学研究院_细胞生物学 | |
| dc.description.note | 学号：21620071151898 | |
