功能性筛选Wingless/Wnt 信号通路的调节因子.

Abstract

生命有机体的发育是高度复杂和精确的过程，受多个信号通路的调控。所有的这些通路是机体器官正常形成及发挥作用所必需的。Wnt/Wingless通路就是其中之一，在发育过程中起重要调控作用。Wnt/Wingless信号通路调控基因表达，在动物界里是高度保守的。Wnt信号通路非常复杂，包含多个成员，一部分成员尚未研究清楚。β-catenin/armadillo就是该通路中的一个重要调控蛋白。当Wnt信号通路被激活时，β-catenin(Armadillo)被转运到核内，与DNA结合蛋白TCF相互作用，启动基因表达，从而调控不同的发育过程。Wnt通路中还存在未知的靶基因或成员。我们利用果蝇筛选希望能够发...

The development of organisms is a highly complex and accurate process. There are many pathways which control the accuracy of developmental processes and are responsible for the normal organogenesis and functioning of an organism. One of these pathways is Wnt/Wingless pathway, which controls many developmental processes actively. Wnt/Wingless pathway is conserved almost throughout the animal kingdo...