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dc.contributor.author阮源萍zh_CN
dc.contributor.author敖小平zh_CN
dc.contributor.author陈安齐zh_CN
dc.contributor.author黄培强zh_CN
dc.date.accessioned2011-04-26T08:04:19Z
dc.date.available2011-04-26T08:04:19Z
dc.date.issued2001-12zh_CN
dc.identifier.citation分析化学,2001(12):1398-1401zh_CN
dc.identifier.issn0253-3820zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/2782
dc.description.abstract以基碳酸酰氯作衍生化试剂 ,采用高效液相色谱拆分 1,1′ 联萘 2 ,2′ 二酚光学异构体。当采用LichrosorbSi 6 0 (4mm× 30 0mm ,5 μm)柱 ,紫外 2 75nm检测 ,正己烷 乙醇 (98.5 1.5 ,V V)为流动相 ,1,1′ 联萘 2 ,2′ 二酚单基碳酸酯的分离因子和分离度分别为 1.36 8、3.0 5 1;用正己烷 乙醚 (98.5 1.5 ,V V)为流动相 ,1,1′ 联萘 2 ,2′ 二酚双基碳酸酯的分离因子和分离度分别为 1.0 5 5、1.347。这一方法可简便、快速地测定联萘二酚单基碳酸酯拆分样品的光学纯度.  1 ,1′2Binaphthalene22 ,2′2diol2mono2[ (2)2menthyl ] carbonate (3) and 1 ,1′2binaphthalene22 ,2′2diol2 bis2[ (2)2menthyl ] carbonate (4) are intermediates in the chemical resolution of racemic 1 ,1′2binaphthalene22 ,2′2 diols (1) utilizing (2)2( 1R)2menthyl chloroformate ( 2) as the derivating agent . In this paper , the optical separation of compound (3) and (4) has been investigated by high performance liquid chromatography on Lichrosorb Si260 (4 mm i . d. ×300 mm , 5 μm) and YWG2CN (4 mm i . d. ×250 mm , 10 μm) column with hexane2polar regulator mixture as an eluent . The results show that the optical isomers of compound (3) and (4) can be well separated. The optical isomers first eluted are (S , 1R′)23 and (S , 1R′, 1R″)24 respectively. The influence of polar solvents and their ratios in the mobile phase on the resolution is examined. This method has been applied to determine the optical purity of 1 ,1′2binaphthalene22 ,2′2diol2mono2[ (2)2menthyl ] carbonate obtained from a novel resolution process.zh_CN
dc.description.sponsorship国家自然科学基金重点资助项目 (No .2 983 2 0 2 0 )zh_CN
dc.language.isozhzh_CN
dc.publisher中国化学会、中国科学院长春应用化学研究所zh_CN
dc.subject高效液相色谱zh_CN
dc.subject衍生化1zh_CN
dc.subject1′2联萘22zh_CN
dc.subject2′2二酚zh_CN
dc.subject联萘二酚单 基碳酸酯zh_CN
dc.subject联萘二酚双 基碳酸酯zh_CN
dc.subject光学异构体拆分zh_CN
dc.subjectHigh performance liquid chromatographyzh_CN
dc.subjectderivatizationzh_CN
dc.subject1′2binaphthalene22zh_CN
dc.subject1′2binaphthalene22zh_CN
dc.subject,2′2diol2mono2[ (2)2menthyl ] carbonatezh_CN
dc.subject1′2binaphthalene22zh_CN
dc.subject2′2diol2bis2[ (2)2menthyl ] carbonatezh_CN
dc.subjectoptical isomer separationzh_CN
dc.subject2′2diolzh_CN
dc.title衍生化高效液相色谱法拆分1,1′-联萘-2,2′-二酚光学异构体zh_CN
dc.title.alternativeSeparation of 1,1'-Binaphthalene-2,2'-diol Optical Isomers by Derivatization High Performance Liquid Chromatographyzh_CN
dc.typeArticlezh_CN


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