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dc.contributor.advisor张其清
dc.contributor.advisor侯振清
dc.contributor.author周春晓
dc.date.accessioned2016-02-14T02:12:54Z
dc.date.available2016-02-14T02:12:54Z
dc.date.issued2011-12-01 17:42:34.0
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/21976
dc.description.abstract磷脂复合物作为一种新的给药体系,可以通过磷脂与药物之间发生的弱相互作用,而改善药物的一些药学特性,也可通过两者发生的较强的作用,而形成不同于原药和磷脂的新物质。复合物的形成能使药物作用时间延长,生物利用度提高,增加药物的脂溶性,还可以降低药物的不良反应。本文利用溶剂挥发法制备了丝裂霉素大豆卵磷脂(MMC-SPC)纳米复合物,并对其药效作用进行了初步研究。本文完成的工作主要包括以下几个方面: (1)MMC-SPC纳米复合物的制备和表征:制备MMC-SPC纳米复合物溶液,并通过正交试验筛选处方,得到的药物磷脂复合物在水中分散体系呈现粒径均一的多层囊结构,平均粒径为210nm,Zeta电荷为-34...
dc.description.abstractPhytosome is a new drug delivery system. Many natural drugs (especially some types of flavonoids) may exhibit a marked affinity for phospholipids. Phytosome, means drug-phospholipid complexes, may enhance the absorption of the drugs and show some superior chemico-physicial properties. In this paper, mitomycin C-lecithin nanocomplex, which can stabilize mitomycin C (MMC) were prepared by a new emul...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=30990&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=29439
dc.subject丝裂霉素
dc.subject大豆卵磷脂
dc.subject纳米复合物
dc.subject溶剂挥发法
dc.subjectMitomycin C (MMC)
dc.subjectsoybean phosphatidylcholine(SPC)
dc.subjectnanocomplex
dc.subjectsolvent evaporation method
dc.title丝裂霉素大豆卵磷脂纳米复合物的制备及其性能的研究
dc.title.alternativeStudies on the Preparation and Properties of MMC-SPC nanocomplex
dc.typethesis
dc.date.replied2011-05-28
dc.description.note学位:理学硕士
dc.description.note院系专业:材料学院生物材料系_生物医学工程
dc.description.note学号:31420081150634


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