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dc.contributor.advisor张其清
dc.contributor.author蔡建春
dc.date.accessioned2016-02-14T02:12:14Z
dc.date.available2016-02-14T02:12:14Z
dc.date.issued2011-02-16 15:21:34.0
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/21693
dc.description.abstract恶性肿瘤的主要特征是浸润和转移。根据文献报道,在浸润和转移过程中,基底膜和细胞外基质(ECM)的降解是关键环节。基质金属蛋白酶-9(MMP-9)作为蛋白水解酶的一种,它能特异性降解基底膜和ECM成分,从而促进肿瘤的浸润、转移及间质血管新生。胃癌组织MMP-9检测结果与临床病理资料对比研究表明,该酶的表达往往与胃癌的分化程度、病理类型、临床病理分期、浸润、转移和预后有关。但是,MMP-9在RNA干扰后对胃癌的影响机制尚不清楚。 RNA干扰是通过dsRNA介导的同源mRNA降解引起的相应转录后基因沉默,它被认为是一种广泛存在于酵母、真菌、植物、动物体内的生物防御机制。据报道,应用RNA干扰技术...
dc.description.abstractThe major characteristics of malignant tumour cells are invasion and metastasis, of which proteolytic degradation of the extracellular matrix (ECM), including basement membrane by matrixmetall -oproteinases (MMPs) is one of the essential events. As a kind of MMPs, matrixmetalloproteinase-9 (MMP-9) can specifically degradate ECM and basement membrane, which would facilitate the invasion, metastasis...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=26663&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=27786
dc.subject胃肿瘤
dc.subject基质金属蛋白酶-9
dc.subjectRNA干扰
dc.subjectBoyden小室
dc.subject原位种植
dc.subject裸鼠
dc.subjectStomach neoplasm
dc.subjectMMP-9
dc.subjectRNA interference
dc.subjectBoyden chamber
dc.subjectOrthotopic implantation
dc.subjectnude mice
dc.title基于RNA干扰技术的MMP-9基因沉默胃癌细胞克隆
dc.title.alternativeEstablishment of gastric carcinoma cell clone with MMP-9 gene silence based on RNA interference
dc.typethesis
dc.date.replied2010-06-07
dc.description.note学位:理学博士
dc.description.note院系专业:化学化工学院材料科学与工程系_高分子化学与物理
dc.description.note学号:B200436003


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