Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives
Shen, Ruwei（Natl Inst Adv Ind Sci & Technol, Tsukuba）
Xu, Qing（Natl Inst Adv Ind Sci & Technol, Tsukuba）
Goto, Midori（Natl Inst Adv Ind Sci & Technol, Tsukuba）
Han, Li-Biao（Natl Inst Adv Ind Sci & Technol, Tsukuba）
- 化学化工－已发表论文 
The reaction of H-phosphinates and secondary phosphine oxides with amines and alcohols proceeds highly stereospecifically to give the corresponding coupling products with inversion of configuration at the phosphorus center under the Atherton-Todd reaction conditions. This finding leads to the establishment of a general and efficient method for the synthesis of a variety of optically active organophosphorus acid derivatives from the easily available chiral H-phosphinates and secondary phosphine oxides.