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dc.contributor.author罗羽(中国人民解放军第三军医大学护理学院)
dc.contributor.author王仙园(中国人民解放军第三军医大学护理学院)
dc.contributor.author杨云青
dc.date.accessioned2013-05-22T00:56:20Z
dc.date.available2013-05-22T00:56:20Z
dc.date.issued2013-02
dc.identifier.citation护理研究,2013,27(2A):292-295zh_CN
dc.identifier.issn1009-6493
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/18684
dc.description.abstract综述了国外在糖尿病重要并发症糖尿病肾病的肾纤维化病变发病机制方面的最新进展,指出多元醇糖代谢支路与醛糖还原酶的异常激活、转化生长因子-β(TGF-β)/Smad信号转导途径的异常激活可能是糖尿病肾病肾脏炎症和肾纤维化病变的主要机制,此外,miR-NAs也可能通过影响TGF-β信号转导途径达到影响糖尿病肾病肾纤维化病变进程的作用。[英文文摘]It reviewed the foreign latest progress on the pathogenesis of renal fibrosis lesions in diabetic nephropathy of important diabetic complications.And it pointed out that abnormal polyhydric alcohol sugar metabolism branch and abnormal activation of aldose reductase,abnormal activation of TGF-β/Smad signal transduction pathways may be main mechanisms of kidney inflammation in diabetic nephropathy and renal fibrosis lesions.In addition,miRNAs may also influence the renal fibrosis process in diabetic nephropathy through impacting the TGF-βsignal transduction pathways.zh_CN
dc.description.sponsorship国家973项目资助,编号:2009CB9416010;国家自然科学基金,编号:30970649;福建省科研基金资助,编号:2010L0002;厦门大学细胞应激生物学国家重点实验室开放课题基金;细胞生物学与肿瘤细胞工程教育部重点实验室访问学者基金资助zh_CN
dc.language.isozhzh_CN
dc.publisher《护理研究》编辑部zh_CN
dc.subject糖尿病肾病zh_CN
dc.subject发病机制zh_CN
dc.subject醛糖还原酶zh_CN
dc.subject转化生长因子-βzh_CN
dc.subjectdiabetic nephropathyzh_CN
dc.subjectpathogenesizh_CN
dc.subjectaldose reductasezh_CN
dc.subjectTGF -beta;;miRNAszh_CN
dc.title糖尿病肾病肾纤维化病变的发病机制研究进展zh_CN
dc.title.alternativeResearch progress on pathogenesis of renal fibrosis in patients with diabetic nephropathyzh_CN
dc.typeArticlezh_CN


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