Show simple item record

dc.contributor.author杨心督zh_CN
dc.contributor.author陈汉zh_CN
dc.contributor.author张惠珠zh_CN
dc.contributor.author高福平zh_CN
dc.contributor.author王银松zh_CN
dc.contributor.author张其清zh_CN
dc.date.accessioned2013-05-20T01:37:32Z
dc.date.available2013-05-20T01:37:32Z
dc.date.issued2007-11-08zh_CN
dc.identifier.citation中国新药杂志, 2007, (21): 1780-1783+1787zh_CN
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/18069
dc.description.abstract目的:合成聚乙二醇单甲醚接枝壳聚糖(monomethoxy poly(ethylene glycol)-grafted-chitosan,mPEG-g- CS),并制备自组装纳米球。方法:利用甲醛连接法将聚乙二醇单甲醚(monomethoxy poly(ethylene glycol),mPEG)接枝干壳聚糖(ehitosan,CS)分子,得到聚乙二醇(poly(ethylene glycol),PEG)改性的壳聚糖衍生物,并通过傅立叶红外光谱仪(Fourier transform infrared spectroscopy,FT-IR),核磁共振仪(proton nuclear magnetic resonance,~1H-NMR)对产物进行结构表征;采用超声透析法制备自组装纳米球,并通过透射电镜(transmission electron microscopy,TEM),动态激光粒度分析仪(dynamic laser light scattering,DLLS)表征了纳米球的形态和粒径;以芘为荧光探针,通过荧光检测分析测定了mPEG-g-CS的临界胶束浓度(critical micellar concentration,CMC)。结果:通过FT-IR,~1H- NMR确证了接枝产物的存在;mPEG-g-CS在水溶液中能够自组装形成球状纳米胶束,平均粒径为250 nm。结论:通过甲醛连接法制备mPEG-g-CS,具有制备方法简捷、反应周期短、易操作的优点。利用该产物制备的纳米球有望成为长循环纳米药物载体。zh_CN
dc.language.isozhzh_CN
dc.source.urihttp://epub.cnki.net/grid2008/brief/detailj.aspx?filename=ZXYZ200721017&dbname=CJFQ2007zh_CN
dc.subject壳聚糖zh_CN
dc.subject聚乙二醇单甲醚zh_CN
dc.subject自组装zh_CN
dc.subject纳米zh_CN
dc.subject长循环zh_CN
dc.title聚乙二醇单甲醚接枝壳聚糖自组装纳米球的制备zh_CN
dc.typeArticlezh_CN


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record