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dc.contributor.authorLi Huanan
dc.contributor.authorLi Qianyan
dc.contributor.authorHou Wei
dc.contributor.authorZhang Jingni
dc.contributor.authorYu Chenhao
dc.contributor.authorZeng Deping
dc.contributor.authorLiu Gang
dc.contributor.authorLi Faqi
dc.date.accessioned2020-10-10T03:14:52Z
dc.date.available2020-10-10T03:14:52Z
dc.date.issued2019-11-20
dc.identifier.citationACS applied materials & interfaces,2019,(46)
dc.identifier.other10.1021/acsami.9b15460
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/177543
dc.description.abstractStimulus-responsive drug delivery nanosystems (DDSs) are of great significance in improving cancer therapy for intelligent control over drug release. However, among them, many DDSs are unable to realize rapid and sufficient drug release because most internal stimulants might be consumed during the release process. To address the plight, an abundant supply of stimulants is highly desirable. Herein, a core crosslinked pullulan-di-(4,1-hydroxybenzylene)diselenide nanosystem, which could generate abundant exogenous-stimulant reactive oxygen species (ROS) via tumor-specific NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, was constructed by the encapsulation of β-lapachone. The enzyme-catalytic-generated ROS induced self-triggered cascade amplification release of loaded doxorubicin (DOX) in the tumor cells, thus achieving efficient delivery of DOX to the nuclei of tumor cells by breaking the diselenide bond of the nanosystem. As a result, the antitumor effect of this nanosystem was significantly improved in the HepG2 xenograft model. In general, this study offers a new paradigm for utilizing the interaction between the loaded agent and carrier in the tumor cells to obtain self-triggered drug release in the design of DDSs for enhanced cancer therapy.
dc.language.isozh_CN
dc.subjectCancer therapy
dc.subjectCascade amplification drug release
dc.subjectCore crosslinked
dc.subjectExogenous-stimulant
dc.subjectΒ-lapachone
dc.titleEnzyme-Catalytic Self-Triggered Release of Drugs from a Nanosystem for Efficient Delivery to Nuclei of Tumor Cells.
dc.typeArticle


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