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dc.contributor.authorWang Ye
dc.contributor.authorWu Xingdong
dc.contributor.authorHong Kunyao
dc.contributor.authorFu Xiaochun
dc.contributor.authorChen Tianhua
dc.contributor.authorZhu Min
dc.contributor.authorYe Huiming
dc.date.accessioned2020-10-10T03:14:50Z
dc.date.available2020-10-10T03:14:50Z
dc.date.issued2019-12-18
dc.identifier.citationClinical biochemistry,2019,
dc.identifier.other10.1016/j.clinbiochem.2019.09.003
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/177528
dc.description.abstractBACKGROUND(#br)This 4-year retrospective cohort study aimed to establish reference intervals for free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) in premature infants using the Beckman Coulter Unicel DxI 800 automated immunoassay system.(#br)METHODS(#br)Study subjects included 605 preterm infants with a gestational age of 26-36 weeks (corrected: 29-38 weeks). Pearson correlation was used to evaluate the association between hormone levels and gestational and corrected gestational ages. A nonparametric method was used to establish reference intervals based on corrected gestational age.(#br)RESULTS(#br)FT3 and FT4 levels were positively correlated with gestational and corrected gestational ages, respectively. TSH levels were slightly negatively correlated with gestational and corrected gestational ages. FT3 significantly differed according to corrected gestational age (29-33 weeks vs 34-38 weeks); however, the difference was smaller than the reference change value (RCV) for the FT3 test. Thus, we combined the FT3 reference intervals into a single reference interval: 2.65-4.93 pmol/L (29-38 weeks). The reference intervals of FT4 and TSH were 11.20-24.97 pmol/L (29-38 weeks) and 1.01-10.14 mIU/L (29-38 weeks), respectively.(#br)CONCLUSIONS(#br)Unlike those of full-term infants or adults, the reference intervals established in this study are applicable in premature infants. These results highlight the importance and complexity of establishing instrument-specific thyroid hormone reference intervals for preterm infants.
dc.language.isozh_CN
dc.subjectFree thyroxine
dc.subjectFree triiodothyronine
dc.subjectPreterm infant
dc.subjectReference interval
dc.subjectThyrotropin
dc.titleEstablishment of reference intervals for thyroid hormones in premature infants beyond the first week of life using Beckman Coulter Unicel DxI 800.
dc.typeArticle


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