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红树内生真菌BYY-1中一个酚类化合物的分离鉴定与抗肿瘤活性
Study on the Isolation Identification and Antitumor Activity of a Phenol Derivative from Mangrove Fungus BYY-1

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红树内生真菌BYY_1中一个酚类化合物的分离鉴定与抗肿瘤活性.pdf (729.4Kb)
Date
2011-11
Author
杜希萍(集美大学生物工程学院)
赵保兵
郑忠辉
徐庆妍
苏文金(集美大学生物工程学院)
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  • 生命科学-已发表论文 [5878]
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Abstract
[中文文摘]采用硅胶柱层析、薄层层析、Sephadex LH-20柱层析从红树内生真菌BYY-1的次级代谢产物中分离到化合物B1.通过乙酰化、NMR、HR ESI-Q-TOF MS等技术鉴定了化合物B1的结构,确定其为首次从红树内生真菌中分离到的化合物.运用MTT法和流式细胞术研究了化合物B1的抗肿瘤活性,结果表明,化合物B1可显著抑制Hela细胞的增殖[英文文摘]Compound B1 was obtained from the secondary metabolites of mangrove fungus BYY -1 using silica gel column chromatography,thin layer chromatography and Sephadex LH - 20 column chromatography.The structure of compound B1 was elucidated by acetylation,NMR and HR ESI -Q -TOF MS analysis,and compound B1 was isolated from mangrove fungi for the first time. The antitumor activity of compound B1 was studied by the methods of MTT and flow cytometric DNA analysis. The results showed compound B1 could significantly inhibit the proliferation of Hela cells with IC50 3. 3 μg /mL,and induce evident Hela cells apoptosis when compound B1 was 4 μg /mL.
Description
[作者简介] 杜希萍( 1978—) ,女,讲师,从事天然产物化学方面的研究. 通讯作者: 苏文金( 1956—) ,男,教授,从事海洋药物与食品方向研究,E-mail: wjsu@ jmu. edu. cn.中央高校基本业务费资助项目(2010121092); 福建省科技计划重点项目(2011N1008);; 集美大学博士启动基金资助项目(ZQ2011004)
Citation
集美大学学报(自然科学版), 2011,16(6):424-428
URI
https://dspace.xmu.edu.cn/handle/2288/17671

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