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dc.contributor.authorYan Congcong
dc.contributor.authorYuan Jiahui
dc.contributor.authorXu Jiajia
dc.contributor.authorZhang Gongye
dc.contributor.authorLi Xiaomei
dc.contributor.authorZhang Bing
dc.contributor.authorHu Tianhui
dc.contributor.authorHuang Xiaohua
dc.contributor.authorMao Yubin
dc.contributor.authorSong Gang
dc.date.accessioned2020-10-10T02:09:24Z
dc.date.available2020-10-10T02:09:24Z
dc.date.issued2019-10-21
dc.identifier.citationMedical oncology (Northwood, London, England),2019,(11)
dc.identifier.other10.1007/s12032-019-1308-7
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/174866
dc.description.abstractOvarian cancer is one of the most lethal gynecological cancers; owning to its late detection and chemoresistance, understanding the pathogenesis of this malignant tumor is much critical. Previous studies have reported that ubiquitin-specific peptidase 39 (USP39) is generally overexpressed in a variety of cancers, including hepatocellular carcinoma, gastric cancer and so forth. Furthermore, USP39 is proved to be associated with the proliferation of malignant tumors. However, the function and mechanism of USP39 in ovarian cancer have not been elucidated. In the present study, we observed that USP39 was frequently overexpressed in human ovarian cancer and was highly correlated with TNM stage. Suppression of USP39 markedly inhibited the growth and migration of ovarian cancer cell lines HO-8910 and SKOV3 and induced cell cycle G2/M arrest. Moreover, knockdown of USP39 inhibited ovarian tumor growth in a xenograft model. In addition, our findings indicated that cell cycle arrest induced by USP39 knockdown might be involved in p53/p21 signaling pathway. Furthermore, we found that the depletion of USP39 inhibited the migration of ovarian cancer cells via blocking epithelial-mesenchymal transition. Taken together, these results suggest that USP39 may play vital roles in the genesis and progression and may serve as a potential biomarker for diagnosis and therapeutic target of ovarian cancer.
dc.language.isozh_CN
dc.subjectEMT
dc.subjectGrowth and migration
dc.subjectHuman ovarian cancer
dc.subjectUSP39
dc.subjectP53/p21 pathway
dc.titleUbiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT.
dc.typeArticle


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