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An exaggerated epinephrine-adrenergic receptor signaling impairs uterine decidualization in mice.

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An_exaggerated_epinephrine_adrenergic_receptor_signaling_impairs_uterine_decidualization_in_mice.pdf (10.61Mb)
Date
2019-12-11
Author
Wu Jinxiang
Kong Shuangbo
Guo Chuanhui
Wang Jianqi
Lu Jinhua
Jiang Ruiwei
Wang Haibin
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  • 药学院-已发表论文 [661]
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Abstract
Our understanding of the relationship between stress-derived epinephrine and early pregnancy failure remains incomplete. Here, we explored the effect of epinephrine exposure on early pregnancy and pseudopregnancy in mice. Increased expression of adrenergic receptors Adra1b, Adra2b and Adrb2 was observed during decidualization and post-implantation embryogenesis was delayed or survival impaired. Epinephrine treatment also impaired decidualization in both the gravid and pseudopregnant uterus, suggesting the effect on decidualization was independent of the conceptus. This included a suppression of endometrial stroma cell proliferation and of key decidualization regulators, including COX2, BMP2 and WNT4. Collectively, these data demonstrate that maternal epinephrine exposure during early pregnancy impairs uterine decidualization and embryo development, underlying early pregnancy failure.
Citation
Reproductive toxicology (Elmsford, N.Y.),2019,
URI
https://dspace.xmu.edu.cn/handle/2288/174831

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