Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice.
Date
2019-12-13Author
Liao Bao-Qiong
Liu Chao-Bin
Xie Shu-Juan
Liu Yu
Deng Ya-Bin
He Shu-Wen
Fu Xian-Pei
Fu Bin-Bin
Wang Ya-Long
Chen Ming-Huang
Lin Yan-Hong
Li Fei-Ping
Xie Xi
Hong Xin-Ru
Wang Hai-Long
Collections
- 药学院-已发表论文 [663]
Abstract
Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM2.5 exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.