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dc.contributor.authorPeng Axiang
dc.contributor.authorGao Yuehong
dc.contributor.authorZhuang Xiaomei
dc.contributor.authorLin Yaoqi
dc.contributor.authorHe Wencan
dc.contributor.authorWang Yannan
dc.contributor.authorChen Wenfan
dc.contributor.authorChen Tingting
dc.contributor.authorHuang Xiaoqing
dc.contributor.authorYang Renzhi
dc.contributor.authorHuang Yuanpeng
dc.contributor.authorXi Shengyan
dc.contributor.authorZhang Xian
dc.date.accessioned2020-10-10T02:09:16Z
dc.date.available2020-10-10T02:09:16Z
dc.date.issued2019-12-27
dc.identifier.citationFrontiers in pharmacology,2019,
dc.identifier.other10.3389/fphar.2019.01391
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/174818
dc.description.abstractAlzheimer’s disease (AD) is the most common neurodegenerative disorder associated with aging. There are currently no effective treatments for AD. Bazhu decoction (BZD), a traditional Chinese medicine (TCM) formula, has been employed clinically to alleviate AD. However, the underlying molecular mechanisms are still unclear. Here we found that middle- and high-doses of BZD ameliorated the behavioral aspects of 5xFAD transgenic mice in elevated plus maze, Y maze and Morris water maze tests. Moreover, BZD reduced the protein levels of BACE1 and PS1, resulting in a reduction of Aβ plaques. We also identified a beneficial effect of BZD on oxidative stress by attenuating MDA levels and SOD activity in the brains of 5xFAD mice. Together, these results indicate that BZD produces a dose-dependent positive effect on 5xFAD transgenic mouse model by decreasing APP processing and Aβ plaques, and by ameliorating oxidative damage. BZD may play a protective role in the cognitive and anxiety impairments and may be a complementary therapeutic option for AD.
dc.language.isozh_CN
dc.subject5xFAD mice
dc.subjectAlzheimer’s disease (AD)
dc.subjectBazhu decoction
dc.subjectTraditional Chinese medicine (TCM)
dc.subjectΒ-amyloid (Aβ)
dc.titleBazhu Decoction, a Traditional Chinese Medical Formula, Ameliorates Cognitive Deficits in the 5xFAD Mouse Model of Alzheimer's Disease.
dc.typeArticle


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