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dc.contributor.authorBao-Qiong Liao
dc.contributor.authorChao-Bin Liu
dc.contributor.authorShu-Juan Xie
dc.contributor.authorYu Liu
dc.contributor.authorYa-Bin Deng
dc.contributor.authorShu-Wen He
dc.contributor.authorXian-Pei Fu
dc.contributor.authorBin-Bin Fu
dc.contributor.authorYa-Long Wang
dc.contributor.authorMing-Huang Chen
dc.contributor.authorYan-Hong Lin
dc.contributor.authorFei-Ping Li
dc.contributor.authorXi Xie
dc.contributor.authorXin-Ru Hong
dc.contributor.authorHai-Long Wang
dc.date.accessioned2020-10-10T02:09:14Z
dc.date.available2020-10-10T02:09:14Z
dc.date.issued2019-12-30
dc.identifier.citationEnvironment International,2019,
dc.identifier.other10.1016/j.envint.2019.105338
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/174810
dc.description.abstractAbstract(#br)Fine particulate matter (PM 2.5 ) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM 2.5 exposure on female reproduction, we exposed female mice to PM 2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM 2.5 , which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM 2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.
dc.language.isozh_CN
dc.subjectPM 2.5
dc.subjectOvary
dc.subjectEmbryo
dc.subjectOocyte
dc.subjectMice
dc.titleEffects of fine particulate matter (PM 2.5 ) on ovarian function and embryo quality in mice
dc.typeArticle


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