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microRNA-632调控TFF1表达并促进胃癌血管生成
microRNA-632 regulates TFF1 and promotes angiogenesis in gastric cancer

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microRNA-632调控TFF1表达并促进胃癌血管生成.pdf (473.5Kb)
Date
2018-02-28
Author
黄肖肖
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  • 医学院-学位论文 [896]
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Abstract
目前胃癌是世界上第五大常见癌症,并且是导致癌症相关死亡的第三大病因。尽管随着诊断方法和治疗手段不断提升,胃癌的发病率和死亡率有一定程度下降,但是胃癌患者的预后仍旧不够理想,特别是进展期胃癌。胃癌死亡的主要原因是胃癌细胞的局部侵袭和远处转移,而血管生成在癌细胞的侵袭转移过程中具有至关重要的作用,不仅可以促进原位肿瘤的生长,也可以增加远处转移的概率。因此,从抑制血管生成角度探讨胃癌细胞转移与侵袭的调控有助于提高胃癌的治疗与预后。 三叶因子(TFFs)家族是一系列由哺乳动物的胃肠道分泌的小分子多肽,在不同生理和病理过程中发挥不同的功能。其中三叶因子1(TFF1)是由胃黏液细胞分泌的可溶性蛋白,生理...
 
Gastric cancer is currently the fifth most common cancer in the world and is the third leading cause of cancer-related death. The invasion and distant metastasis of cancer cells are the major cause of cancer deaths. Although in recent years with the diagnosis of gastric cancer and treatment methods continue to improve, the morbidity and mortality has been declined, but the prognosis of stamoch can...
 
URI
https://dspace.xmu.edu.cn/handle/2288/170976

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