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dc.contributor.advisor郑辉
dc.contributor.advisor孙灏
dc.contributor.author高月
dc.date.accessioned2018-12-05T01:50:04Z
dc.date.available2018-12-05T01:50:04Z
dc.date.issued2018-04-09
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/170974
dc.description.abstract摘要 目的:SNX27作为一种重要的分选蛋白,主要参与膜受体从内涵体重新转运到细胞膜上的过程,SNX27的缺失会导致到突触受体循环过程受到阻碍。本研究通过构建人SNX27转基因小鼠探讨过表达SNX27对于突触功能的影响。 方法:采用SNX27转基因小鼠作为研究对象,通过Camk2a启动子诱导人SNX27基因在小鼠皮层以及海马中过表达。在一月龄SNX27转基因小鼠和WT小鼠海马脑片上检测CA1区锥体神经元(Pyramidalneuron)的微小兴奋性/抑制性突触后电流(miniatureexcitatory/inhibitorypostsynapticcurrents,mEPSCs/mIPS...
dc.description.abstractAbstract Objective:Among sorting nexin family proteins, SNX27 is a unique one as it plays crucial role in sorting and recycling transmembrane proteins from endosome-to-plasma membrane. SNX27 deficiency disrupts trafficking of synaptic receptors and leads to synaptic dysfunction. In this study, we will determine the functions of SNX27 using aSNX27 transgenic mouse model. Method:In order to stud...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=59811&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=61127
dc.subjectSNX27
dc.subjecthippocampus
dc.subjectsynaptic plasticity
dc.subjectlearning and memory
dc.subjectSNX27
dc.subject海马
dc.subject突触可塑性
dc.subject学习记忆
dc.titleSNX27调节突触传导和突触可塑性
dc.title.alternativeSNX27 regulates synaptic transmission and plasticity
dc.typethesis
dc.date.replied2017-05-18
dc.description.note学位:理学硕士
dc.description.note院系专业:医学院_微生物学
dc.description.note学号:24520141153461


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