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TFF3通过结合蛋白AKR1C1介导促进胃癌细胞增殖及侵袭转移
TFF3 promotes cell proliferation and invasion via interacting with AKR1C1

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TFF3通过结合蛋白AKR1C1介导促进胃癌细胞增殖及侵袭转移.pdf (615.1Kb)
Date
2018-04-12
Author
陈大军
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  • 医学院-学位论文 [896]
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Abstract
胃癌是全球四大肿瘤之一,是全球癌症相关死亡的主要原因之一。在全球范围内发病率排在第四,癌症引起的死亡病例中排名第二。大部分胃癌患者在诊断时属于进展期失去了手术时机,或者有切除术后出现复发性疾病。对于晚期患者大部分存在扩散转移,局部辅助治疗或新辅助治疗通常与手术结合进行,预后差,患者的中位生存期约为1年。所以寻找早期诊断及有效靶向治疗是近几年胃癌研究的热点。 三叶因子3(TFF3)是胃肠道中特异性表达的三叶因子家族蛋白中的一员,TFF3主要在肠道黏膜分泌,在胃黏膜中未检测到表达,但在胃癌中表达升高。TFF3作为一种癌基因,与胃癌的发生发展密切相关,通过NF-κB、EGFR及PI3K-Akt等多...
 
Gastric cancer is one of the most common cancers in the world and one of the most common causes of cancer-related deaths worldwide. Globally, gastric cancer ranks fourth in cancer incidence, Gastric cancer is the second leading cause of cancer deaths. The majority of gastric cancer patients have reached advanced stage when diagnosed, losing the best time of surgery, or having a high recurrence rat...
 
URI
https://dspace.xmu.edu.cn/handle/2288/170965

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