电离辐射诱导肺癌内外环境变化的组蛋白甲基化重塑规律
Reprogramming of Global Histone Methylation During the Variation of Internal and External Environment Induced by Ionizing Radiation in Lung Cancer
Abstract
肺癌是当今社会威胁人类健康的重大恶性疾病之一，其主要治疗方式为放射治疗。然而，肺癌易产生辐射耐受，严重限制放疗的治疗效果。从基因学角度对肺癌细胞辐射抗性产生机制的研究已有很多，但是基因网络错综复杂，对有效的靶向分子和调控通路仍没有清晰的阐述。肿瘤外环境也是辐射抗性产生的影响因素之一，肿瘤内外环境同时发生病理改变最终导致肿瘤恶化和辐射抗性产生。因此，深入探讨肿瘤内外环境协同作用机制对于解决辐射抗性问题十分必要，而从表观遗传学角度进行探索将是一个全新的方向。组蛋白共价修饰作为表观遗传修饰方式之一，介导了染色质结构的重塑和基因的转录调控，但其在肺癌辐射抗性的产生机制及肺癌细胞外环境病理改变中的作用机... Lung cancer is now the most common malignant that threatens human health worldwide. Radiotherapy is the mainstay of curative lung cancer treatments, but radio-resistance and tumor relapse after radiotherapy seriously restricts the therapeutic effect. A large number of evidence show that the mechanism of radio-resistance to lung cancer cells can be attributed to genetic alteration. However, the gen...