川芎嗪对神经病理痛大鼠的镇痛作用及对背根节神经元电压门控钙通道的影响

Abstract

目的：应用脊神经结扎（Spinalnerveligation，SNL）制作神经病理痛（Neuropathicpain，NP）大鼠模型，给予不同剂量川芎嗪（Tetramethylpyzine，TMP）治疗，检测神经病理痛大鼠的机械缩足反应阈值（Mechanicalwithdrawlthreshold，MWT）和热缩足潜伏期（Thermalwithdrawllatency，TWL）及伴随的抑郁行为，探讨川芎嗪对神经病理痛的镇痛作用，神经病理痛模型大鼠是否表现出抑郁行为，及川芎嗪是否对伴随神经病理痛的抑郁症状具有抗抑郁效果。采用全细胞膜片钳技术检测川芎嗪对背根神经节（Dorsalrootgangli...

Objective: The rat model of neuropathic pain was made by sciatic nerve ligation (SNL). In order to study the analgesic effect of tetramethylpyrazine on neuropathic pain, whether the neuropathic pain model will show depressive behaviors and whether tetramethylpyrazine has antidepressant effects on depressive symptoms associated with neuropathic pain, different doses of tetramethylpyrazine was give...