肺癌中menin对P53的调控规律及生物学意义研究

Abstract

肺癌（Lungcancer）和肝细胞癌（HepatocellularCarcinoma，HCC）都是世界上最常见的六大恶性肿瘤之一，也是人类最主要的致死原因之一。多发性内分泌肿瘤1型综合征（multipleendocrineneoplasiatype1，MEN1）是一种以甲状旁腺、垂体前叶瘤、胰岛等内分泌器官肿瘤为特征的家族性常染色体疾病，其关键的致病基因之一是MEN1基因，该基因编码menin蛋白。我们实验室发现在肺癌中MEN1作为一个典型的抑癌基因发挥抑癌作用，同时menin抑制肺神经内分泌肿瘤的分化，而在肝细胞肝癌中MEN1则作为癌基因发挥促癌作用。因此，阐明menin在不同癌症系统中不...

Lung cancer and Hepatocellular Carcinoma (HCC) are one of the six most common malignancies in the world and one of the most important causes of death in humans. Multiple endocrine neoplasia type 1 (MEN1) is a familial autosomal disease characterized by endocrine organ tumors such as parathyroid, anterior pituitary tumor and islet, and its key pathogenic genes is MEN1, which encodes the menin prote...