PM2.5对哮喘中初始T细胞分化的影响

Abstract

支气管哮喘(asthma)，简称哮喘，是一种以气道高反应性和可逆性气道阻塞为特点的慢性炎症性疾病。虽然对哮喘发病机制和治疗的研究取得了很大进展，但全世界哮喘发病率和死亡率仍呈现上升趋势。哮喘的发病危险因素包括遗传因素（内因）和环境因素（外因）两个方面。环境因素作为诱发哮喘和哮喘急性发作的重要危险因素，主要包括过敏原、气候变化和空气污染等。PM2.5致病的主要原因是由于细颗粒物粒径小，比表面积大，活性强，容易吸附空气中的各类有毒成分。我们前期研究发现PM2.5、PM10等空气污染物浓度与儿童呼吸系统疾病的门诊量呈显著正相关趋势。哮喘发病机制较为复杂，目前主要分为以下几点：气道炎症机制，免疫及变态...

Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness and reversible airway obstruction. Although great progress has been made in the study of the pathogenesis and treatment of asthma, the incidence and mortality of asthma are increasing in the world. The risk factors of asthma include two aspects: genetic factors (internal factors) and environmental factors (externa...