K48泛素化甘露糖受体在尼古丁增强树突状细胞交叉提呈中的作用研究

Abstract

树突状细胞（Dendriticcells，DCs）作为适应性免疫应答的始动者，其所诱生的CD8+T细胞应答是机体抗胞内病原微生物感染和抗肿瘤的主要效应细胞。其中，DCs对外源性抗原的交叉提呈是启动CD8+T细胞应答的必要条件，而甘露糖受体（Mannosereceptor，MR）介导的抗原内体转位及内体对p97、Sec61的招募是DCs交叉提呈的关键环节。我们的前期研究发现，微量的尼古丁能通过上调MR表达并进而促进MR介导的抗原内体转位及内体对p97、Sec61的招募。已有文献报道，外源性抗原的负载可促进MR的泛素化并进而可能在抗原内体转位及内体对p97、Sec61的招募中发挥作用。但到目前为止...

Dendritic cells (DCs) are known as initiators of adaptive immunity. In addition to classical MHC I-restricted endogenous antigen presentation, Surface molecules such as lectin, CD40, langerin, heat shock protein mediated cross-presentation allows DCs presenting intracellular antigen and induces protective immunity against intracellular microbes infection or against tumors. Cross-presentation by de...