β-淀粉样蛋白通过与TREM2结合而诱导小胶质细胞的迁移
Amyloid-β induces microglial migration by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
Date
2018-04-09Collections
- 医学院－学位论文 [896]
Abstract
髓系细胞触发受体2（Triggeringreceptorexpressedonmyeliodcells2，TREM2）是一种先天免疫受体蛋白，在大脑内主要表达于小胶质细胞表面。据报道，TREM2编码区的突变能够增加罹患阿尔兹海默症（Alzheimer’sDisease，AD）、纳苏-哈科罗症（Nasu-HakolaDisease，NHD）和其他神经退行性疾病的风险。虽然有许多TREM2的配体陆续被报道，但目前关于内源性TREM2配体的鉴定及其生理学功能的研究仍然知之甚少。 在本研究中，我们首先构建了羧基端带有Fc标签的可溶性胞外段的TREM2（SolubleTREM2-Fc，sTREM2-F... Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor selectively expressed by microglia in the brain. The coding variants of TREM2 have been reported to increase the risk for Alzheimer’s disease (AD), Nasu-Hakola disease (NHD) and other neurodegenerative diseases. While many TREM2 ligands have been proposed, the identification of bona fide endogenous TREM2 ligands ...