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dc.contributor.advisor卜国军
dc.contributor.advisor陈小芬
dc.contributor.author李新秀
dc.date.accessioned2018-12-05T01:49:54Z
dc.date.available2018-12-05T01:49:54Z
dc.date.issued2018-04-09
dc.identifier.urihttps://dspace.xmu.edu.cn/handle/2288/170896
dc.description.abstract载脂蛋白E(apolipoproteinE,apoE)是脑中主要的载脂蛋白及胆固醇运载体。人类APOE基因具有多态性,包含了APOEɛ2、ɛ3和ɛ4三种亚型。其中,ɛ4等位基因是引起晚发型阿尔茨海默病(Late-onsetAlzheimer’sDisease)最重要的危险因素。尽管许多研究表明在老年人中APOE基因的多态性与认知功能密切相关,但其对青少年群体认知功能的影响研究非常少,并且有限的研究结果存在争议性。为了进一步探讨APOE基因多态性对儿童认知功能的影响,我们招募了了571名10-12岁中国小学生,并对他们的APOE基因型与学科学习成绩进行相关...
dc.description.abstractApolipoprotein E (apoE) is a major apolipoprotein and a cholesterol carrier in the brain. Human APOE gene is polymorphic and it exists in three major isoforms: ε2, ε3, ε4. The ɛ4 allele is the strongest risk factor for late-onset Alzheimer’s disease. Although it has been widely recognized that APOE polymorphic alleles are associated with cognitive impairment in the elderly people, there have ...
dc.language.isozh_CN
dc.relation.urihttps://catalog.xmu.edu.cn/opac/openlink.php?strText=59821&doctype=ALL&strSearchType=callno
dc.source.urihttps://etd.xmu.edu.cn/detail.asp?serial=60010
dc.subjectAPOE基因型
dc.subject学业成绩
dc.subject体育成绩
dc.subjectDAP12
dc.subjectTREM2
dc.subjectJNK
dc.subjectLPS
dc.subject小胶质细胞
dc.subject炎症
dc.subjectAPOE genotype
dc.subjectacademic performance
dc.subjectphysical education performance
dc.subjectDAP12
dc.subjectTREM2
dc.subjectJNK
dc.subjectLPS
dc.subjectmicroglia
dc.subjectinflammation
dc.titleAPOE基因亚型与小学生学习成绩的相关性研究、TREM2/DAP12复合物在小胶质细胞中的信号通路研究
dc.title.alternativeAssociation of APOE genotype with academic and physical education performance; The role of TREM2/DAP12 complex in microglial signaling pathway
dc.typethesis
dc.date.replied2017-05-22
dc.description.note学位:理学硕士
dc.description.note院系专业:医学院_微生物学
dc.description.note学号:24520141153445


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