• 中文
    • English
  • English 
    • 中文
    • English
  • Login
View Item 
  •   DSpace Home
  • 医学院
  • 医学院-学位论文
  • View Item
  •   DSpace Home
  • 医学院
  • 医学院-学位论文
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

基于实时荧光定量PCR技术的早期梅毒活动性和疗效评价
Evaluation of Therapeutic Efficacy and Disease Activity in Early Syphilis Based on Real-time Quantitative PCR

Thumbnail
Full Text
基于实时荧光定量PCR技术的早期梅毒活动性和疗效评价.pdf (673.1Kb)
Date
2018-02-28
Author
朱晓桢
Collections
  • 医学院-学位论文 [896]
Show full item record
Abstract
背景:至今,梅毒活动性和疗效评价依然困难,缺乏梅毒疗效评判标准,临床上通常采用血清非特异性抗体滴度和/或滴度四倍下降作为参考指标。然而,有关梅毒患者在梅毒螺旋体(Treponemapallidum,T.pallidum)自然感染过程中非特异性抗体变化仍然不清。本研究建立T.pallidum感染早期梅毒兔模型,监测自然感染和抗生素治疗过程中血清RapidPlasmaReagin(RPR)滴度和皮损中核酸载量变化,以及不同脏器中梅毒螺旋体核酸的分布,并进一步采用脏器标本接种新西兰兔观察感染率和疗效,探究实时荧光定量PCR技术在早期梅毒活动性和疗效判断中的应用价值。 方法:选择梅毒血清抗体阴性的新...
 
Background: Currently, the assessment of the syphilis activity and treatment are extremely difficult and lack of efficacy evaluation criteria. Therefore, clinicians usually, used serum nontreponemal test antibody titers and its four-fold decline in titers as a judgment index for syphilis activity and treatment efficacy evaluation. However, the dynamic change of the nontreponemal test antibody tite...
 
URI
https://dspace.xmu.edu.cn/handle/2288/170888

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

copyright © 2002-2016  Duraspace  Theme by @mire  厦门大学图书馆  
About | Policies