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基于氧化应激机制研究MnTBAP对绝经后骨质疏松发生发展的影响
Research the effect of MnTBAP on the occurrence and development of postmenopausal osteoporosis basing on the mechanism of oxidative stress

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基于氧化应激机制研究MnTBAP对绝经后骨质疏松发生发展的影响.pdf (468.3Kb)
Date
2018-04-12
Author
曹祥昌
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  • 医学院-学位论文 [896]
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Abstract
摘要 目的:立足于氧化应激这一重要发病机制,研究抗氧化物质MnTBAP对绝经后 骨质疏松发生发展的作用。 方法:本课题内容由动物实验和细胞实验组成。动物实验中,基于卵巢切除去 势后的绝经后骨质疏松模型,对随机分组后的实验动物SD大鼠行相应的造模处 理及药物干预,6周后处死实验动物并取材。通过western-blot技术评估药物干 预下各组实验动物骨组织中Mn-SOD的表达水平,并通过血清及骨组织匀浆中 的AOPP(晚期高级氧化蛋白)、MDA(丙二醛)、SOD(超氧岐化酶)相关 量化指标的检测反映各组实验动物相应的氧化应激水平变化。同时行骨组织中 BMP-2(骨形成蛋白-2)的...
 
Abstract Objective:Basing on the important pathogenesis of oxidative stress,to study the effect of antioxidant MnTBAP on postmenopausal osteoporosis development. Methods: This study is composed of animal experiment and cell experiment.In animal experiments,basing on postmenopausal osteoporosis model of ovariectomized OVX ,the experimental animals SD rats were randomly divided and gived line ...
 
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https://dspace.xmu.edu.cn/handle/2288/170883

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