油酰乙醇胺改善大鼠球囊损伤后新生内膜的形成
Effect of Oleoylethanolamide on neointimal formation after balloon injury in rats
Abstract
研究背景： 动脉粥样硬化(Atherosclerosis，AS)的病理发展进程是一种慢性炎症反应，且是内皮损伤后的一系列进行性疾病。油酰乙醇胺（Oleoylethanolamide，OEA）是一种存在于组织和循环血液的内源性脂肪酸乙醇胺类化合物。已有大量文献报道，OEA具有降低脂质代谢，调节饮食、降低体重、神经保护及延长寿命等多种生物学作用。但是OEA抗动脉粥样硬化的作用及机制尚未可知。本论文分别通过体内体外实验，探究了OEA对血管损伤后新生内膜的形成及由血小板衍生生长因子（Plateletderivedgrowthfactor，PDGF）诱导的大鼠原代主动脉平滑肌细胞（RatVascula... Background: The pathogenesis of atherosclerosis (AS) is a chronic inflammatory response and is a series of progressive diseases after endothelial injury. Oleoylethanolamide (OEA) is an endogenous fatty acid ethanolamine compound present in tissue and circulating blood. OEA has a variety of biological effects such as lowering lipid metabolism, regulating diet, reducing body weight, neuroprotection ...