缺氧在高脂喂养小鼠肝脏脂质代谢中的作用及机制研究

Abstract

背景：非酒精性脂肪性肝病（NAFLD）是指除外酒精和其他明确的损肝因素所致的，以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合症。然而NAFLD的发病机制并不明确，目前比较公认的是“二次打击”学说。近年来，有文献报道缺氧与肝脏脂质代谢密切相关，并且在临床中肥胖病人和呼吸暂停综合症（OSA）病人同时患有非酒精性脂肪肝的概率非常高。 目的：根据高脂饮食（highfatdiet，HFD）与NAFLD疾病的关系，探索HFD跟缺氧之间的联系以及缺氧在脂肪肝发病过程中所起的作用，研究缺氧诱导肝脏脂质堆积的机制。 材料与方法：1.高脂模型：使用60%高脂饲料喂养的小鼠和0.4mM棕榈酸诱导的肝原代细胞...

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) refers to the clinical pathology syndrome without alcohol and other clear liver damage factors, characterized by diffuse hepatic steatosis. The pathogenesis of NAFLD is still not very clear, however, most theories are based on the ‘two-hit hypothesis’. Interestingly, some studies have shown that hypoxia is closely related to hepatic lipid metab...