心肌炎中高密度脂蛋白(HDL-C)异常及对炎症程度影响的初步探讨
The preliminary study of the High-density Lipoprotein (HDL - C) changes on Myocarditis and possible mechanism
Abstract
【目的】心肌炎是指各种原因引起的心肌的炎症性病变,轻症患者无任何症状,而重症患者可发生心力衰竭、心源性休克甚至猝死,目前其发病机制仍未完全明确,临床上也没有特异性的治疗手段。血脂代谢紊乱在动脉硬化性心血管病中的研究较多,但在心肌炎中的作用研究较少。本课题拟对心肌炎中的血脂代谢情况进行初步探讨,并进一步与心肌炎的炎症程度进行相关性分析,为心肌炎诊断和治疗提供新思路。 【方法】本研究分两部分内容:(一)临床研究:选取2013-2016年入住我院诊断明确的急性心肌炎患者,对照组选取健康体检患者,分为急性心肌炎组n=110,正常对照组n=30,对炎症指标CRP、心肌损伤标志物CK-MB/cTnT水平... 【Objective】Myocarditis is an inflammatory heart disease that poses many risks to humans. It is progressive, can cause severe heart failure, arrhythmia, shock, and death. The pathogenesis of myocarditis is not clear now and there is no specific treatment for myocarditis. Dyslipidemia plays an important role in the pathogenesis of atherosclerosis and other cardiovascular disease. However, rare resea...