神经生长因子促进糖尿病大鼠角膜神经的修复
Nerve growth factor promotes the repair of corneal nerves in diabetic rats
Abstract
摘要 目的：探究神经生长因子（NerveGrowthFactor，NGF）对糖尿病大鼠角膜神经的作用，并解释其作用分子机制。 方法：SD大鼠腹腔注射链脲佐菌素（Streptozotocin，STZ）建立Ⅰ型糖尿病大鼠模型，模型建立成功后将正常大鼠和糖尿病大鼠眼球分为四组，正常大鼠左、右眼分别为Ctrl+BSA组和Ctrl+NGF组，糖尿病大鼠左、右眼分别为DM+BSA组和DM+NGF组，并在实验条件下饲养。第6周末检测四组角膜敏感度，然后分别在大鼠左、右眼滴加浓度15ug/mL的牛血清白蛋白（BovineSerumAlbumin，BSA）溶液、NGF溶液，连续2周，每天3次，每次2... Abstract Objective: To explore the effect of nerve growth factor (NGF) on corneal nerves of diabetic rats, and to explain the molecular mechanism. Methods: Type 1 diabetes model rats were induced by intraperitoneal injection of streptozotocin (STZ). Six weeks after the model were successfully established, corneal sensitivity were tested between the control and diabetic rats, then the left or...